Cagrilintide: Effective Weekly Dosage and Weight Loss Benefits Explained Once weekly cagrilintide for weight management in people with overweight and obesity: a multicentre, randomised, double blind, placebo controlled and active controlled, dose finding phase 2 trial The Lancet Cagrilintide, an amylin analog, enhances the weight loss effects of semaglutide or tirzepatide by slowing gastric emptying, suppressing glucagon, and reducing appetite. It works synergistically with Cagrilintide and semaglutide together drive record weight loss in global trial