Cagrilintide: The Peptide That Makes You Forget About Food. I call it the silence between cravings. Cagrilintide is a long acting amylin analog which means it works alongside leptin and GLP 1 to Novo Nordisk's CagriSema Leads to Superior Weight Loss in REDEFINE 1 Trial Cagrilintide (AM833) Long acting amylin analog. Beta cells make TWO hormones: insulin and amylin. Amylin slows stomach emptying and reduces appetite. Cagrilintide is a long acting synthetic amylin designed for once weekly dosing Coadministered Cagrilintide and Semaglutide in Adults with Overweight or Obesity New England Journal of Medicine