Nitrite reverses nitroglycerin tolerance via repletion of a nitrodilator activated nitric oxide store in vascular smooth muscle cells ScienceDirect Not too big. Not too small. Because of their intermediate size, macrocyclic peptides combine the potency and precise targeting of an antibody or biologic therapy with the stability and ease of administration of a TOLERANCE & TACHYPHYLAXIS The tripeptide GHKCu complex ameliorates lipopolysaccharideinduced acute lung injury in mice Oncotarget